Energy resource management under the influence of the weekend transition considering an intensive use of electric vehicles

Energy resource scheduling is becoming increasingly important, as the use of distributed resources is intensified and of massive electric vehicle is envisaged. The present paper proposes a methodology for day-ahead energy resource scheduling for smart grids considering the intensive use of distributed generation and Vehicle-to-Grid (V2G). This method considers that the energy resources are managed by a Virtual Power Player (VPP) which established contracts with their owners. It takes into account these contracts, the users' requirements subjected to the VPP, and several discharge price steps. The full AC power flow calculation included in the model takes into account network constraints. The influence of the successive day requirements on the day-ahead optimal solution is discussed and considered in the proposed model. A case study with a 33-bus distribution network and V2G is used to illustrate the good performance of the proposed method

A DNA-Based T Cell Receptor Reveals a Role for Receptor Clustering in Ligand Discrimination

A T cell mounts an immune response by measuring the binding strength of its T cell receptor (TCR) for peptide-loaded MHCs (pMHC) on an antigen-presenting cell. How T cells convert the lifetime of the extracellular TCR-pMHC interaction into an intracellular signal remains unknown. Here, we developed a synthetic signaling system in which the extracellular domains of the TCR and pMHC were replaced with short hybridizing strands of DNA. Remarkably, T cells can discriminate between DNA ligands differing by a single base pair. Single-molecule imaging reveals that signaling is initiated when single ligand-bound receptors are converted into clusters, a time-dependent process requiring ligands with longer bound times. A computation model reveals that receptor clustering serves a kinetic proofreading function, enabling ligands with longer bound times to have disproportionally greater signaling outputs. These results suggest that spatial reorganization of receptors plays an important role in ligand discrimination in T cell signaling

Spin and orbital dynamics through the metal-to-insulator transition in Cd2_2Os2_2O7_7 probed with high-resolution RIXS

High-resolution resonant inelastic x-ray scattering (RIXS) measurements ($\Delta$E = 46 meV) have been performed on Cd$_2$Os$_2$O$_7$ through the metal-to-insulator transition (MIT). A magnetic excitation at 125 meV evolves continuously through the MIT, in agreement with recent Raman scattering results, and provides further confirmation for an all-in, all-out magnetic ground state. Asymmetry of this feature is likely a result of coupling between the electronic and magnetic degrees of freedom. We also observe a broad continuum of interband excitations centered at 0.3 eV energy loss. This is indicative of significant hybridization between Os 5$d$ and O 2$p$ states, and concurrent itinerant nature of the system. In turn, this suggests a possible break down of the free-ion model for Cd$_2$Os$_2$O$_7$.Comment: Accepted in Physical Review B (10 pages

The importance of XY anisotropy in Sr2IrO4 revealed by magnetic critical scattering experiments

The magnetic critical scattering in Sr$_2$IrO$_4$ has been characterized using X-ray resonant magnetic scattering (XRMS) both below and above the 3D antiferromagnetic ordering temperature, T$_{\text{N}}$. The order parameter critical exponent below T$_{\text{N}}$ is found to be \beta=0.195(4), in the range of the 2D XYh$_4$ universality class. Over an extended temperature range above T$_{\text{N}}$, the amplitude and correlation length of the intrinsic critical fluctuations are well described by the 2D Heisenberg model with XY anisotropy. This contrasts with an earlier study of the critical scattering over a more limited range of temperature which found agreement with the theory of the isotropic 2D Heisenberg quantum antiferromagnet, developed to describe the critical fluctuations of the conventional Mott insulator La$_2$CuO$_4$ and related systems. Our study therefore establishes the importance of XY anisotropy in the low-energy effective Hamiltonian of Sr$_2$IrO$_4$, the prototypical spin-orbit Mott insulator.Comment: 6 pages, 4 figure

Clinical effectiveness and cost-effectiveness of imatinib dose escalation for the treatment of unresectable and/or metastatic gastrointestinal stromal tumours that have progressed on treatment at a dose of 400 mg/day : a systematic review and economic evaluation

Peer reviewedPublisher PD

Modeling the Control of Trypanosomiasis Using Trypanocides or Insecticide-Treated Livestock

In Uganda, cattle are an important reservoir for Trypanosoma brucei rhodesiense, the causative agent of Rhodesian sleeping sickness (human African trypanosomiasis), transmitted by tsetse flies Glossina fuscipes fuscipes, which feed on cattle, humans, and wild vertebrates, particularly monitor lizards. Trypanosomiasis can be controlled by treating livestock with trypanocides or insecticide – killing parasites or vectors, respectively. Mathematical modeling of trypanosomiasis was used to compare the impact of drug- and insecticide-based interventions on R0 with varying densities of cattle, humans and wild hosts. Intervention impact changes with the number of cattle treated and the proportion of bloodmeals tsetse take from cattle. R0 was always reduced more by treating cattle with insecticide rather than trypanocides. In the absence of wild hosts, the model suggests that control of sleeping sickness (R0<1) could be achieved by treating ∼65% of cattle with trypanocides or ∼20% with insecticide. Required coverage increases as wild mammals provide increasing proportion of tsetse bloodmeals: if 60% of non-human bloodmeals are from wild hosts then all cattle have to be treated with insecticide. Conversely, it is reduced if lizards, which do not harbor trypanosomes, are important hosts and/or if insecticides are used at a scale where tsetse numbers decline

A research agenda for open energy science: Opportunities and perspectives of the F1000Research Energy Gateway [version 1; peer review: not peer reviewed]

Energy enables the functioning of modern society. However, humanity’s reliance on fossil fuels since the industrial revolution has contributed to many societal problems including climate change, environmental degradation and pollution, and the transition to a renewable and carbon-free energy system is one of the grand challenges for the 21st century. The aim of this editorial is to outline the importance of a fast and transparent sharing of energy research and discuss key themes of the Energy Gateway of F1000Research

Dinâmica de frações de fósforo em latossolos de cerrado com diferentes históricos de uso.

O histórico de uso e a mineralogia do solo podem modificar a dinâmica das formas de P, em função de diferenças na energia de ligação com os colóides do solo. No presente estudo objetivou-se quantificar frações lábeis de P e avaliar a participação dessas no crescimento do feijoeiro em Latossolos com diferentes históricos de uso. Os solos foram coletados na profundidade de 0-20 cm em áreas cultivadas por longos períodos, com calagem e adubações fosfatadas periódicas e, também, em áreas adjacentes não cultivadas (cerrado nativo). Foi conduzido um experimento com cada solo concomitantemente, obedecendo a um delineamento inteiramente casualizado, num esquema fatorial 2 x 4 (duas condições de histórico de uso do solo e quatro doses de P) com quatro repetições. Os tratamentos foram constituídos por duas condições de histórico de uso do solo (não cultivado ou cultivado) e quatro doses de P (0, 120, 240 e 480 mg dm-3), na fonte superfosfato triplo. Amostras de solo foram tomadas antes e após o cultivo do feijão, e o fósforo no solo foi quimicamente fracionado. A adição de doses crescentes de P aos solos promove aumento das frações orgânicas e inorgânicas de P bicarbonato. A fração de Po constituiu em fonte de P para o crescimento do feijão e, sendo a magnitude de uso dessa fração dependente da interação entre tipo de solo, histórico de uso e manejo do solo

Biochemical parameters of silver catfish (Rhamdia quelen) after transport with eugenol or essential oil of Lippia alba added to the water

The transport of live fish is a routine practice in aquaculture and constitutes a considerable source of stress to the animals. The addition of anesthetic to the water used for fish transport can prevent or mitigate the deleterious effects of transport stress. This study investigated the effects of the addition of eugenol (EUG) (1.5 or 3.0 mu L L-1) and essential oil of Lippia alba (EOL) (10 or 20 mu L L-1) on metabolic parameters (glycogen, lactate and total protein levels) in liver and muscle, acetylcholinesterase activity (AChE) in muscle and brain, and the levels of protein carbonyl (PC), thiobarbituric acid reactive substances (TBARS) and nonprotein thiol groups (NPSH) and activity of glutathione-S-transferase in the liver of silver catfish (Rhamdia quelen; Quoy and Gaimard, 1824) transported for four hours in plastic bags (loading density of 169.2 g L-1). The addition of various concentrations of EUG (1.5 or 3.0 mu L L-1) and EOL (10 or 20 mu L L-1) to the transport water is advisable for the transportation of silver catfish, since both concentrations of these substances increased the levels of NPSH antioxidant and decreased the TBARS levels in the liver. In addition, the lower liver levels of glycogen and lactate in these groups and lower AChE activity in the brain (EOL 10 or 20 mu L L-1) compared to the control group indicate that the energetic metabolism and neurotransmission were lower after administration of anesthetics, contributing to the maintenance of homeostasis and sedation status.Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS/PRONEX) [10/0016-8]; Conselho Nacional de Pesquisa e Desenvolvimento Cientifico (CNPq) [470964/2009-0]; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES); CNPqinfo:eu-repo/semantics/publishedVersio